Lithopone, a chemical compound with a rich history, emerges as a vital substance in various industries. Comprising barium sulfate and zinc sulfide, this compound boasts unique properties that make it a popular choice in applications such as paints, inks, and plastics. Recognized for its exceptional opacity and brightness, lithopone significantly enhances the covering power of materials in which it is incorporated. Its inert nature and resistance to atmospheric influences contribute to its longevity in diverse formulations. As a white pigment, lithopone plays a pivotal role in achieving vibrant and enduring colors across a spectrum of products, marking it as a cornerstone in the realm of chemical compounds.

Titanium dioxide is a mineral that’s used as a white coloring in a variety of products, including sunscreens, cosmetics, paints, and plastics. The pigment grade is also known as titanium white, pigment white 6, or CI 77891; it's the whitest and brightest of all known pigments.

The integrity of surface skin cells was evaluated with and without solar simulated irradiation. The integrity of the stratum corneum was significantly lower in individuals treated with P25TiO₂NPs under the light in comparison to the ones that received the functionalized nanoparticles. Cell membrane suffering is evident (Fig. 9), and it is in accordance with the ROS levels and macromolecule oxidation found in vitro for the irradiated P25TiO₂NPs. Disruption of the superficial skin layer was observed in all animals treated with no functionalized nanoparticles, under irradiation. This data expands the findings by the group of Professors Fubini and Fenoglio, who showed that P25TiO₂NPs could impact the lipid structure at the top few microns of the stratum corneum [55]. Control skin under irradiation and without any topic formulation did not show changes in cell structure.